Director, Clinical Sciences

Company: Maze Therapeutics
Location: South San Francisco
Posted on: January 9, 2026

Job Description:

The Opportunity Turn insights into action. Advance breakthrough therapies. Maze Therapeutics is looking for a Director, Clinical Sciences to play a hands-on role in advancing our APOL1 program for chronic kidney disease. You will design and implement clinical studies, author protocols and regulatory documents, and collaborate with investigators and advocacy groups to ensure operational excellence. Working closely with cross-functional partners, you’ll help translate genetic insights into actionable clinical plans and deliver high-quality data that drives program success. This role offers the chance to contribute directly to the development of a first-in-class therapy while growing your expertise in clinical development within a fast-paced, mission-driven environment. In addition to our APOL1 program, Maze Therapeutics has an exciting pipeline focused on renal, cardiac, and metabolic diseases, including a second precision medicine for kidney disease that is following closely behind APOL1. This role offers the opportunity to contribute across multiple programs advancing medical breakthroughs with high potential for impact and transforming lives. This position reports to the Senior Medical Director, Clinical Sciences. The Impact You’ll Have Participate in the design, execution, and analysis of clinical trials for the APOL1 program and other clinical stage assets at Maze Author and review clinical-regulatory documents, including protocols and amendments, informed consents, study reports, and SAPs Prepare and deliver scientific presentations and other communication materials for internal and external stakeholders, including investigators and other Maze collaborators. Collaborate with scientific thought leaders and patient advocacy groups to gain insights that inform clinical development plans and foster awareness and enthusiasm for the Maze pipeline. Partner with Clinical Development Operations to identify and select study investigators and sites and cultivate strong, trust-based relationships with study investigators. Partner with Clinical Development Operations to identify, select, and oversee vendors and CROs to support program needs. Lead the development and integration of timelines and budgets for clinical activities, ensuring alignment with overall company goals and cross-functional input from project management, CMC, nonclinical development, regulatory affairs, and other stakeholders. As a Director, we also expect our leaders to demonstrate the following Leadership Competencies: Communication and Influence Builds communication channels across Maze for sharing information Influences Senior Management decisions through persuasive arguments Respectfully addresses differing opinions leading to support of decision Teamwork and Collaboration Champions partnerships and connections across Maze Proactively addresses issues that could result in breakdown of team relationships Spotlights team and individual contributions in public forums Execution and Results Addresses gaps and leverages strengths to get best results Maintains a steadying presence and clarifies priorities during change Anticipates and removes barriers that put functional/corporate goals at risk Develop Others and Self Removes barriers to staff development and empowers them to make their own decisions Stays current on industry trends and keeps direct-reports prepared and responsive What We’re Looking For Advanced degree in health sciences (PhD/MD/PharmD) with a minimum of 3 years of drug development industry experience. Experience in the design and conduct of clinical trials, including preparation of study-specific documents and training materials, data monitoring and review, and assessment of protocol deviations. Experience in clinical data analysis and scientific presentations. A strong commitment to building collaborative relationships with investigators, site study staff, patient advocacy groups, and other third parties. Exceptional organizational, analytical, and communication skills, enabling you to translate corporate objectives into actionable plans that consistently deliver high-quality data on time and within budget. A proactive and adaptable mindset with a commitment to ethical standards and a focus on team and corporate success. Willingness to travel domestically and internationally (up to approximately 20%) for vendor visits, industry conferences, regulatory meetings, advisory boards, and other essential gatherings. About Maze Therapeutics Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco. Our People Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. Our Core Values Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission. Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. Stand True – Our integrity is foundational; it guides us no matter the obstacle. The expected annual salary range for employees located in the San Francisco Bay Area is $245,000 to $295,000. Additionally, this position is eligible for an annual performance bonus. Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future. Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy. LI-Hybrid

Keywords: Maze Therapeutics, Woodland , Director, Clinical Sciences, Science, Research & Development , South San Francisco, California